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GPI anchor

GPI biosynthesis defects

a rare monogenic disorder

GPIBDs

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Welcome to the IGSB

Welcome to the Institute for Genomic Statistics and Bioinformatics. We are convinced that precision medicine can only be achieved when human and artificial intelligence join efforts. Please have a look at our research and get in contact if you have any questions or would like to collaborate!

Jan 11, 2021

Researchers create an animal model for studying GPI anchor deficiencies

Impaired intelligence, movement disorders and developmental delays are typical for a group of rare diseases that belong to GPI anchor deficiencies. Researchers from the University of Bonn and the Max Planck Institute for Molecular Genetics used genetic engineering methods to create a mouse that mimics these patients very well. Studies in this animal model suggest that in GPI anchor deficiencies, a gene mutation impairs the transmission of stimuli at the synapses in the brain. This may explain the impairments associated with the disease.

Dec 30, 2020

Intelligence deficit: Conclusion from the mouse to the human being

Impaired intelligence, movement disorders and developmental delays are typical for a group of rare diseases that belong to GPI anchor deficiencies. We used genetic engineering methods to create a mouse that mimics these patients very well. Studies in this animal model suggest that in GPI anchor deficiencies, a gene mutation impairs the transmission of stimuli at the synapses in the brain. This may explain the impairments associated with the disease.

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